361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study elucidates the structural and physicochemical determinants governing CCT domain specificity in WNK signaling, revealing distinct binding classes, a novel motif for the second WNK CCT domain, and the existence of a similar FERRY3 domain, thereby establishing a broader framework for understanding these protein-protein interactions.
This study reveals that de novo lipogenesis regulates the export of lysosomal enzymes from the endoplasmic reticulum by providing fatty acids for Arf1 myristoylation, which is essential for maintaining the retrograde Golgi-to-ER trafficking required for efficient enzyme transport.
This study demonstrates that the recently proposed three-step detour pathway for dolichol biosynthesis is evolutionarily conserved in budding yeast through the identification of TDA5 as the functional ortholog of the human DHRSX gene.
This study reveals that epithelial lumen formation is initiated by the bulk delivery of preassembled, microvilli-rich vacuolar apical compartments (VACs) to the apical membrane initiation site, a process coordinated by the Crumbs complex protein PatJ to ensure rapid and efficient lumenogenesis.
This paper introduces ABDS, a novel, safe, and easily prepared fluorescent dye derived from red permanent marker ink that effectively visualizes both the cytoplasmic membrane and endoplasmic reticulum of eukaryotic cells, offering a high-contrast, stable alternative to commercial dyes like Rhodamine 6G and DiBAC.
This study demonstrates that the conserved nucleoporin NPP-21/TPR is essential for developmental regulation of spindle checkpoint strength in *C. elegans* germline cells by concentrating PCH-2 around mitotic chromosomes and promoting Mad2 localization to unattached kinetochores.
This study reveals that glucose starvation triggers GPI lipid remodeling to supply specific lipids for vacuolar liquid-ordered domain formation via endocytosis, a process essential for regulating lipophagy and preventing lipid droplet accumulation in budding yeast.
This study reveals that in *Aspergillus nidulans*, SsdA-containing mRNPs are transported bidirectionally along microtubules via endosomal hitchhiking and are spatially regulated by NDR kinase CotA signaling to control their distribution relative to hyphal growth rates.
This study reveals that senescent myoblasts maintain mTORC1 activity through a ROS-dependent PI3K/Akt pathway rather than lysosomal nutrient liberation, and while antioxidants can suppress their pro-inflammatory phenotype and restore differentiation, prolonged treatment induces reductive stress-mediated cell death, highlighting redox modulation as a key mechanism for senotherapeutic strategies.
Under lysosomal stress, the Parkinson's disease-associated kinase LRRK2 activates distinct Rab GTPase pathways to drive the subtype-specific secretion of extracellular vesicles containing endolysosomal components, thereby revealing a novel mechanism for stress-induced exocytosis.